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CPT: Pharmacometrics & Systems Pharmacology

Editor-in-Chief: France Mentré, MD, PhD

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  CPT: Pharmacometrics & Systems Pharmacology: Volume 13, Issue 4

  Pages: 505-685

  April 2024

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ISSUE INFORMATION

Open Access

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Issue Information

• Pages: 505-508
• First Published: 12 April 2024

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PERSPECTIVES

LETTER TO THE EDITOR

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Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?

Eunjin Hong,  Paul M. Beringer, 

• Pages: 509-510
• First Published: 21 March 2024

This article relates to:

• Response to “Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?”

  • Magali Amiel, 
  • Volume 13Issue 4CPT: Pharmacometrics & Systems Pharmacology
  • pages: 511-512
  • First Published online: March 21, 2024

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REPLY

Open Access

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Response to “Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?”

Magali Amiel, 

• Pages: 511-512
• First Published: 21 March 2024

This article relates to:

• Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?

  • Eunjin Hong, 
  • Paul M. Beringer, 
  • CPT: Pharmacometrics & Systems Pharmacology
  • pages: 509-510
  • First Published online: March 21, 2024

• Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?

  • Eunjin Hong, 
  • Paul M. Beringer, 
  • CPT: Pharmacometrics & Systems Pharmacology
  • pages: 509-510
  • First Published online: March 21, 2024

• Development of a cystic fibrosis population model for physiologically based pharmacokinetic models: Is it worth it?

  • Eunjin Hong, 
  • Paul M. Beringer, 
  • Volume 13Issue 4CPT: Pharmacometrics & Systems Pharmacology
  • pages: 509-510
  • First Published online: March 21, 2024

• Full text
• PDF
• References
• Request permissions

TUTORIALS

TUTORIALS

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Application of multistate modeling to clinical data analysis

Joachim Grevel,  Joshua Veasy,  Blesson Chacko, 

• Pages: 513-523
• First Published: 12 February 2024

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In silico modeling and simulation of organ-on-a-chip systems to support data analysis and a priori experimental design

Nicoló Milani,  Neil Parrott,  Aleksandra Galetin,  Stephen Fowler,  Michael Gertz, 

• Pages: 524-543
• First Published: 14 February 2024

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RESEARCH

CASE REPORT

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Simulation-based evaluation of personalized dosing approaches for anti-FGFR/KLB bispecific antibody fazpilodemab

Kenta Yoshida,  Victor Poon,  Ajit Dash,  Rebecca Kunder,  Leslie Chinn,  Matts Kågedal, 

• Pages: 544-550
• First Published: 11 February 2024

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ARTICLES

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Population pharmacokinetic modeling of oral brepocitinib in healthy volunteers and patients with immuno-inflammatory diseases

Farzaneh Maleki,  Elias Clark,  Christopher Banfield,  Wonkyung Byon,  Timothy Nicholas, 

• Pages: 551-562
• First Published: 08 February 2024

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Physiologically-based pharmacokinetic modeling of prominent oral contraceptive agents and applications in drug–drug interactions

Gareth J. Lewis,  Deepak Ahire,  Kunal S. Taskar, 

• Pages: 563-575
• First Published: 21 December 2023

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Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling

J. Porter Hunt,  Samuel Dubinsky,  Autumn M. McKnite,  Kit Wun Kathy Cheung,  Bianca D. van Groen,  Kathleen M. Giacomini,  Saskia N. de Wildt,  Andrea N. Edginton,  Kevin M. Watt, 

• Pages: 576-588
• First Published: 29 December 2023

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Open Access

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Physiologically-based pharmacokinetic modeling of the drug–drug interaction between ivacaftor and lefamulin in cystic fibrosis patients

Magali Amiel,  Alice Ke,  Steven P. Gelone,  Hannah M. Jones,  Wolfgang Wicha, 

• Pages: 589-598
• First Published: 01 February 2024

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Tofacitinib pharmacokinetics in children and adolescents with juvenile idiopathic arthritis

Cheng Chang,  Camille Vong,  Xiaoxing Wang,  Anasuya Hazra,  Annette Diehl,  Timothy Nicholas,  Arnab Mukherjee, 

• Pages: 599-611
• First Published: 31 January 2024

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Quantitative modeling of tumor dynamics and development of drug resistance in non-small cell lung cancer patients treated with erlotinib

Anyue Yin,  G. D. Marijn Veerman,  Johan G. C. van Hasselt,  Christi M. J. Steendam,  Hendrikus Jan Dubbink,  Henk-Jan Guchelaar,  Lena E. Friberg,  Anne-Marie C. Dingemans,  Ron H. J. Mathijssen,  Dirk Jan A. R. Moes, 

• Pages: 612-623
• First Published: 20 February 2024

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Evaluation of the drug–drug interaction potential of brigatinib using a physiologically-based pharmacokinetic modeling approach

Michael J. Hanley,  Karen Rowland Yeo,  Meera Tugnait,  Shinji Iwasaki,  Narayana Narasimhan,  Pingkuan Zhang,  Karthik Venkatakrishnan,  Neeraj Gupta, 

• Pages: 624-637
• First Published: 30 January 2024

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Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats

Bruna Bernar Dias,  Fernando Carreño,  Victória Etges Helfer,  Laura Ben Olivo,  Keli Jaqueline Staudt,  Karina Paese,  Fabiano Barreto,  Fabíola Schons Meyer,  Ana Paula Herrmann,  Sílvia Stanisçuaski Guterres,  Stela Maris Kuze Rates,  Bibiana Verlindo de Araújo,  Iñaki F. Trocóniz,  Teresa Dalla Costa, 

• Pages: 638-648
• First Published: 28 January 2024

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Data-driven disease progression model of Parkinson's disease and effect of sex and genetic variants

Ryota Jin,  Hideki Yoshioka,  Hiromi Sato,  Akihiro Hisaka, 

• Pages: 649-659
• First Published: 19 February 2024

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Understanding CYP3A4 and P-gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib

Christine Bowman,  Michael Dolton,  Fang Ma,  Sravanthi Cheeti,  Denison Kuruvilla,  Rucha Sane,  Nastya Kassir,  Yuan Chen, 

• Pages: 660-672
• First Published: 13 March 2024

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A systematic efficacy analysis of tuberculosis treatment with BPaL-containing regimens using a multiscale modeling approach

Maral Budak,  Laura E. Via,  Danielle M. Weiner,  Clifton E. Barry III,  Pariksheet Nanda,  Gabrielle Michael,  Khisimuzi Mdluli,  Denise Kirschner, 

• Pages: 673-685
• First Published: 26 February 2024

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