Clinical Pharmacology & Therapeutics Guide to Authors

Manuscript Preparation Guidelines

Content Types | Manuscript Format | Associated Fees

Editorial Policies

Post-Acceptance Information

Criteria for Publication

The principal criteria for publication of papers in CPT are that they:

• Report original scientific research (the main results and conclusions must not have been previously published)
• Are of outstanding scientific importance
• Reach a conclusion of interest to an interdisciplinary readership
  
  

Manuscript Preparation Guidelines

Submissions that do not adhere to the guidelines provided may be returned to the author prior to consideration.


Submit a Manuscript

Content Types

^*If the word count exceeds the posted limit, please provide overage justification upon submission.

^**By invitation only

Manuscript Format

General format

Manuscripts must be typed in English and be in a single column, double-spaced format. All manuscript pages should be numbered.

Title page

Must include:

1. Complete manuscript title;
2. All authors’ full names and affiliations;
3. Name, address, telephone number, and e-mail address for corresponding author;
4. Conflict of Interest statement (Each author must disclose and describe any involvement, financial or otherwise, that might potentially bias his or her work);
5. Funding information (This should include sources of support, including federal and industry support);
6. Keywords.
   
   

Text

For contributions that do not require an abstract, introductory paragraphs may contain references to cited work. Articles should consist of the following ordered sections:

• Title Page
• Abstract
• Introduction
• Methods (must contain IRB or IACUC approval: see Informed Consent and Ethics)
• Results
• Discussion
• Study Highlights
• Acknowledgements: Medical writers, proofreaders, and editors should not be listed as authors, but acknowledged here.
• Author Contributions: A list of each author's contributions. The standard contributions include: Wrote Manuscript, Designed Research, Performed Research, Analyzed Data, and Contributed New Reagents/Analytical Tools.
• References
• Figure Legends
• Supplementary Information Titles 
  
  

Study Highlights

Articles should include a Study Highlights section after the Discussion in the manuscript text. The highlights section should include and answer each of the questions below. The entire section, not including the questions, should be under 150 words.

• What is the current knowledge on the topic?
• What question did this study address?
• What does this study add to our knowledge?
• How might this change clinical pharmacology or translational science?
  
  

Figures

Figures should be numbered consecutively in the order of first citation in the text. Figures and tables must be uploaded separately from the manuscript text. Each figure must be provided as an individual file. Composite figures should be submitted preassembled. Figure legends should be brief and specific and should appear after the Reference section in the manuscript text.

Accepted figure files include PDF, TIFF, or EPS. Color charges may apply for printed version. Figures supplied in color will appear as such on the web for free. If authors choose to forego color charges, these figures will be converted to black and white for the print journal automatically as part of the regular production process. For any figures that include elements that would become inaccurate due to conversion to gray scale (eg, a color key in a bar graph), separate color and black and white versions should be submitted as well as separate versions of the figure legend where color used in the figure is referred to directly. The black and white versions of figures should be submitted as supplementary information and indicated as such in the cover letter.

Minimum resolutions:

• Halftone images, 300 dpi (dots per inch)
• Color images, 300 dpi saved as CMYK
• Images containing text, 400 dpi
• Line art, 1,000 dpi

Sizes:

• Figure width – single image 86 mm (should be able to fit into a single column of the printed journal)
• Figure width – multi-part image 178 mm (should be able to fit into a double column of the printed journal)
• Text size
• 8 point (should be readable after reduction – avoid large type or thick lines) line width between 0.5 and 1 point

Tables

Tables should be submitted in an editable MS Word DOC or DOCX file. Tables should be numbered consecutively in the order of first citation in the text and multipart tables (Table 1a and 1b) are not allowed. Minimize empty space and restrict the number of characters per row to 130. Supply a brief title for each, but place explanatory matter in the footnotes (not in the heading).

Image Integrity and Standards

Images submitted with a manuscript for review should be minimally processed (for instance, to add arrows to a micrograph). Authors should retain their unprocessed data and metadata files, as editors may request them to aid in manuscript evaluation. If unprocessed data are unavailable, manuscript evaluation may be stalled until the issue is resolved. A certain degree of image processing is acceptable for publication (and for some experiments, fields and techniques is unavoidable), but the final image must correctly represent the original data and conform to community standards. The guidelines below will aid in accurate data presentation at the image processing level; authors must also take care to exercise prudence during data acquisition, where misrepresentation must equally be avoided. Authors should list all image acquisition tools and image processing software packages used. Authors should document key image gathering settings and processing manipulations in the Methods. Images gathered at different times or from different locations should not be combined into a single image, unless it is stated that the resultant image is a product of time-averaged data or a time-lapse sequence. If juxtaposing images is essential, the borders should be clearly demarcated in the figure and described in the legend. The use of touch-up tools, such as cloning and healing tools in Photoshop, or any feature that deliberately obscures manipulations, is to be avoided. Processing (such as changing brightness and contrast) is appropriate only when it is applied equally across the entire image and is applied equally to controls. Contrast should not be adjusted so that data disappear. Excessive manipulations, such as processing to emphasize one region in the image at the expense of others (for example, through the use of a biased choice of threshold settings), is inappropriate, as is emphasizing experimental data relative to the control. When submitting revised final figures, authors may be asked to submit original, unprocessed images.

Supplementary Information

Supplementary information is peer-reviewed material directly relevant to the conclusion of an article that cannot be included in the printed version owing to space or format constraints. It is posted on the journal’s website and linked to the article online; it may include data files, graphics, videos, or extensive tables. The printed article must be complete and self-explanatory without the supplementary information. Use the following naming structure for your supplementary figures and tables: Figure S1 and Table S1, etc. and do not refer to supplementary materials as appendices. Files of supplementary references without accompanying text are not allowed.

Supplementary Information Files

Authors should ensure that supplementary information is supplied in its final format at submission, as it is not copy edited and will appear online exactly as submitted. The number of files is limited to eight, and the total file size should not exceed 8 MB. Individual files should not exceed 1 MB. Questions about the submission or preparation of supplementary information should be directed to the editorial office.

• Supplementary figures must be provided as individual high-resolution PDF, TIFF, or EPS files. Images should not exceed 640 x 480 pixels.
• Supplementary tables must be provided as individual DOC, DOCX, or Excel files.
• Supplementary text must be provided in DOC, DOCX, or PDF files.
• Video files can be in Quick Time (.mov), or MPEG (.mpg) format. For videos, we recommend 480 x 360 pixels as the maximum frame size and a frame rate of 15 frames per second. If applicable to the presentation of the information, use a 256-color palette. Our recommended maximum data rate is 150 KB/s. Seek advice from the editorial office before sending files larger than our maximum size to avoid delays in publication.

Drug Names

Refer to drugs and therapeutic agents by their accepted generic or chemical name, and do not abbreviate them (a proprietary name may be given only with the first use of the generic name). Code names should be used only when a generic name is not yet available (the chemical name and a figure giving the chemical structure of the drug is required). Copyright or trade names of drugs should be capitalized and placed in parentheses after the name of the drug. Names and locations (city and state in United States; city and country outside United States) of manufacturers of drugs, supplies, or equipment cited in a manuscript are required to comply with trademark law and should be provided in parentheses. The official HUGO gene should be indicated in parentheses with the first reference in the paper.

Language Editing

Authors who require editing for language are encouraged to consult language editing services prior to submission.

Permissions

If a table, figure or any other previously published material is included, the authors must obtain written permission to reproduce the material in both print and electronic formats from the copyright owner and submit it with the manuscript. The original source should be cited in full per the terms and conditions as stated in the permission agreement.

Data

Upon submission, the corresponding author must confirm full access to all data in the study and final responsibility. CPT expects that data supporting the results in the paper will be archived in an appropriate public repository. Whenever possible the scripts and other artefacts used to generate the analyses presented in the paper should also be publicly archived. Exceptions may be granted at the discretion of the editor for sensitive information such as human subject data or the location of endangered species. Authors are expected to provide a data accessibility statement, including a link to the repository they have used, to accompany their paper.

References

The reference list should contain the references in the order in which they are cited in the text. Citations included in tables/figures count toward the maximum references allowed for the article type and must be included in the reference list. Tables created solely of references are not permitted.

Only published works, as well as manuscripts in press, should be included in the reference list; articles that are submitted or in preparation should be referred to as “unpublished data” in the text (for which all authors up to 6 total should be listed, then et al.). For publications in the reference list, all authors should be included unless there are more than 6, in which case only the first author should be given, followed by ‘et al.’ Titles of cited articles are required for all article types. Journal names are italicized and abbreviated (with periods after each abbreviated word) according to common usage; refer to Index Medicus (PubMed) for details. For book citations, the publisher and city of publication are required; include the country (and state for US) for lesser-known cities or where any ambiguity is possible (e.g., John Wiley & Sons, Hoboken, New Jersey, USA, 2003; MIT Press, Cambridge, Massachusetts, USA).

CPT supported by endnote styles. To download the CPT file visit http://www.endnote.com/support/enstyles.asp and search for Clinical Pharmacology & Therapeutics.

Examples:

• Journal Articles:
  Kashuba, A.D. et al. Effect of fluvoxamine therapy on the activities of CYP1A2, CYP2D6, and CYP3A as determined by phenotyping.Clin. Pharmacol. Ther.64, 257–268 (1998).
• Website:
  Fleischbein, J. Northeast Pacific long-term observation program. US GLOBEC <http://globec.oce.orst.edu/groups/nep/index.html> (2003). Accessed 13 April 2006.
• Books:
  Eisen, H.N. Immunology: An Introduction to Molecular and Cellular Principles of the Immune Response 5th edn. (Harper & Row, New York, 1974).
• Articles in books:
  Weinstein, L. & Schwartz, M.N. Pathogenic properties of invading microorganisms. In Pathologic Physiology: Mechanisms of Disease (eds. Sodeman, W.A., Jr. & Sodeman, W.A.) 457–473 (W.B. Saunders, Philadelphia, 1974).

Associated Fees

All fees are not applicable to invited manuscripts (excludes original research).

Submission fee

Manuscripts submitted for consideration will incur a submission fee to cover, in part, the time and resources required to manage submissions. Fees must be paid prior to submission of a paper and will not be waived or refunded.

• Non-ASCPT member rate: $75 (plus VAT where applicable)
• ASCPT member rate: $50 (plus VAT where applicable)
  
  

Page charges

Manuscripts accepted for publication will incur page charges to cover, in part, the cost of publication. A charge of $54 will be issued for each journal page.

Color charges

Color images will incur color charges to cover, in part, the cost of publication

Supplementary Information charges

Supplementary information may be included online at a rate of $125 per file.

Open Access Publication

OnlineOpen is available to authors who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author’s funding agency, or the author’s institution pays a fee to ensure the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency’s preferred archive. See the full list of terms and conditions

All OnlineOpen articles are treated in the same way as any other article. They go through the journal’s standard peer-review process and will be accepted or rejected based on their own merit.

Contact Information

Clinical Pharmacology & Therapeutics
528 North Washington Street
Alexandria, VA 22314
Tel: +1.703.836.6981
Email: cpt@ascpt.org