Journal Overview

CPT: Pharmacometrics & Systems Pharmacology (PSP) is an official open access journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT) and International Society of Pharmacometrics (ISoP)

Featured in CPT: Pharmacometrics & Systems Pharmacology

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CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

New Cover for CPT:PSP.

Identification of high-dimensional omics-derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling

A schematic visualization of the proposed two-step approach.

Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility

In silico Model Process flowchart.

Browse Articles

Open access

Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model

Alberto Ippolito, Hanwen Wang, Yu Zhang, Vahideh Vakil, Hojjat Bazzazi, Aleksander S. Popel, 
  •  7 December 2023
Open access

Assessment of CYP3A‐mediated drug interaction via cytokine (IL‐6) elevation for mosunetuzumab using physiologically‐based pharmacokinetic modeling

Yuan Chen, Fang Ma, Nicholas Jones, Rong Deng, Chunze Li, Chi-Chung Li, 
  •  4 December 2023
Open access

Model‐based meta‐analysis using latent variable modeling to set benchmarks for new treatments of systemic lupus erythematosus

Kosalaram Goteti, Ramon Garcia, William R. Gillespie, Jonathan French, Lena Klopp-Schulze, Ying Li, Cristina Vazquez Mateo, Sanjeev Roy, Oliver Guenther, Lisa Benincosa, Karthik Venkatakrishnan, 
  •  4 December 2023
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Open access

Pharmacokinetics of Monoclonal Antibodies

Josiah T. Ryman, Bernd Meibohm, 
  •  576-588
  •  27 June 2017
Open access

Application of ggplot2 to Pharmacometric Graphics

K Ito, D Murphy, 
  •  1-16
  •  16 October 2013
Open access

Basic Concepts in Population Modeling, Simulation, and Model‐Based Drug Development—Part 2: Introduction to Pharmacokinetic Modeling Methods

DR Mould, RN Upton, 
  •  1-14
  •  17 April 2013
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Open access

Evaluation of the Potential Impact on Pharmacokinetics of Various Cytochrome P450 Substrates of increasing IL‐6 Levels following administration of the T‐cell bispecific engager Glofitamab

Neil Parrott, Nassim Djebli, Felix Jaminion, David Carlile, Elena Guerini, Amaury O'Jeanson, 
Open access

Realizing the Promise of Project Optimus: Challenges and Emerging Opportunities for Dose Optimization in Oncology Drug Development

Wei Gao, Jiang Liu, Blerta Shtylla, Karthik Venkatakrishnan, Donghua Yin, Mirat Shah, Timothy Nicholas, Yanguang Cao, 
Open access

An introduction to causal inference for pharmacometricians

James A. Rogers, Hugo Maas, Alejandro Pérez Pitarch, 
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