Clinical Pharmacology & Therapeutics (CPT), the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT), is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics.

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Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg‐Depleting Antibody

  •  20 May 2024

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Vopikitug (RG6292) is a novel CD25-Treg-depleting antibody currently clinically evaluated for its ability to enhance antitumor immunity. This study describes the Entry into Human-enabling framework from in vitro quantification of CD25 and RG6292 pharmacology to in vivo assessment of PK/PD/safety relationships in cynomolgus monkeys leading to the selection of the most appropriate safe starting dose and the projection of the pharmacologically relevant dose range. The first clinical data obtained for RG6292 in patients verified the appropriateness of the described approaches from animal to man.

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