Journal Overview

Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).

Featured in Clinical Pharmacology & Therapeutics

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

Browse Articles

Characteristics of the Compassionate Use Program in Japan: An Analysis of Expanded Access Clinical Trials from 2016 to 2021

Hideki Maeda, Marika Uchida, Mikiko Kusano, Katsura Tsukamoto, Moeka Yamanoi,
  •  15 May 2022

Effect of chronic kidney disease on the renal secretion via organic anion transporters (OAT)1/3: Implications for PBPK modelling and dose adjustment

Shawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin,
  •  15 May 2022
Open access

Recommendations for the management of drug‐drug interactions between the COVID‐19 antiviral nirmatrelvir/ritonavir (Paxlovid®) and comedications

Catia Marzolini, Daniel R. Kuritzkes, Fiona Marra, Alison Boyle, Sara Gibbons, Charles Flexner, Anton Pozniak, Marta Boffito, Laura Waters, David Burger, David J. Back, Saye Khoo,
  •  14 May 2022
Open access

Population pharmacokinetics and pharmacodynamics of the therapeutic and adverse effects of ketamine in patients with treatment‐refractory depression

Ahmad Y Abuhelwa, Andrew A Somogyi, Colleen K Loo, Paul Glue, Daniel T. Barratt, David J.R Foster,
  •  13 May 2022

Clinical implications of altered drug transporter abundance/function and PBPK modeling in specific populations: An ITC perspective

Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, J. Steven Leeder, Dwaipayan Mukherjee, Kunal Taskar, Manthena V. Varma, Xinyuan Zhang, Xinning Yang, Aleksandra Galetin,
  •  13 May 2022
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free access

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk,
  •  127-134
  •  13 May 2015
free access

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang,
  •  1095-1105
  •  17 November 2018
free access

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

JK Hicks, K Sangkuhl, JJ Swen, VL Ellingrod, DJ Müller, K Shimoda, JR Bishop, ED Kharasch, TC Skaar, A Gaedigk, HM Dunnenberger, TE Klein, KE Caudle, JC Stingl,
  •  37-44
  •  20 December 2016
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Characteristics of the Compassionate Use Program in Japan: An Analysis of Expanded Access Clinical Trials from 2016 to 2021

Hideki Maeda, Marika Uchida, Mikiko Kusano, Katsura Tsukamoto, Moeka Yamanoi,

Effect of chronic kidney disease on the renal secretion via organic anion transporters (OAT)1/3: Implications for PBPK modelling and dose adjustment

Shawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin,
Open access

Recommendations for the management of drug‐drug interactions between the COVID‐19 antiviral nirmatrelvir/ritonavir (Paxlovid®) and comedications

Catia Marzolini, Daniel R. Kuritzkes, Fiona Marra, Alison Boyle, Sara Gibbons, Charles Flexner, Anton Pozniak, Marta Boffito, Laura Waters, David Burger, David J. Back, Saye Khoo,
more >

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