Journal Overview

Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).

Featured in Clinical Pharmacology & Therapeutics

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

Browse Articles

Understanding the Mechanism and Extent of Transplacental Transfer of (-)-∆9-Tetrahydrocannabinol (THC) in the Perfused Human Placenta to Predict In Vivo Fetal THC Exposure

Aditya R. Kumar, Emily D. Sheikh, Joshua W. Monson, Sarah E. Ligon, Rebecca L. Talley, Elisabeth M. Dornisch, Kamy J. Howitz, Jennifer R. Damicis, Nicholas Ieronimakis, Jashvant D. Unadkat, 
  •  5 June 2023

Reply to “Interpretation of Pharmacovigilance Disproportionality Analyses”

Viktoryia Prontskus, Audrey Fresse, Mélissa Yelehe, Mathilde Beurrier, Pierre Gillet, 
  •  1 June 2023
No abstract is available for this article.

Interpretation of Pharmacovigilance Disproportionality Analyses

Charles Khouri, Michele Fusaroli, Francesco Salvo, Emanuel Raschi, 
  •  30 May 2023
No abstract is available for this article.

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition

Pablo Mallaroni, Natasha L. Mason, Johannes T. Reckweg, Riccardo Paci, Sabrina Ritscher, Stefan W. Toennes, Eef L. Theunissen, Kim P.C. Kuypers, Johannes G. Ramaekers, 
  •  30 May 2023

Reply to “Questioning Bayesian Inference‐Based Models for Estimating Culprit Drugs for Adverse Drug Reactions”

Kazuki Hamada, Takeshi Abe, Kyoji Kouda, Masahiko Nakatsui, Takashi Kitahara, Kazuto Matsunaga, Yoshiyuki Asai, 
  •  29 May 2023
No abstract is available for this article.
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free access

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk, 
  •  127-134
  •  13 May 2015
free access

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang, 
  •  1095-1105
  •  17 November 2018
free access

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

JK Hicks, K Sangkuhl, JJ Swen, VL Ellingrod, DJ Müller, K Shimoda, JR Bishop, ED Kharasch, TC Skaar, A Gaedigk, HM Dunnenberger, TE Klein, KE Caudle, JC Stingl, 
  •  37-44
  •  20 December 2016
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Understanding the Mechanism and Extent of Transplacental Transfer of (-)-∆9-Tetrahydrocannabinol (THC) in the Perfused Human Placenta to Predict In Vivo Fetal THC Exposure

Aditya R. Kumar, Emily D. Sheikh, Joshua W. Monson, Sarah E. Ligon, Rebecca L. Talley, Elisabeth M. Dornisch, Kamy J. Howitz, Jennifer R. Damicis, Nicholas Ieronimakis, Jashvant D. Unadkat, 

Assessment of the acute effects of 2C-B vs psilocybin on subjective experience, mood and cognition

Pablo Mallaroni, Natasha L. Mason, Johannes T. Reckweg, Riccardo Paci, Sabrina Ritscher, Stefan W. Toennes, Eef L. Theunissen, Kim P.C. Kuypers, Johannes G. Ramaekers, 

Machine Learning Application Identifies Germline Markers of Hypertension in Ovarian Cancer Patients Treated with Carboplatin, Taxane and Bevacizumab

Maurizio Polano, Luca Bedon, Michele Dal Bo, Roberto Sorio, Michele Bartoletti, Elena De Mattia, Erika Cecchin, Carmela Pisano, Domenica Lorusso, Andrea Alberto Lissoni, Andrea De Censi, Sabrina Chiara Cecere, Paolo Scollo, Sergio Marchini, Laura Arenare, Ugo De Giorgi, Daniela Califano, Elena Biagioli, Paolo Chiodini, Francesco Perrone, Sandro Pignata, Giuseppe Toffoli, 
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