Clinical Pharmacology & Therapeutics (CPT), the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT), is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics.

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

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Value of Pharmacogenetic Testing Assessed with Real‐World Drug Utilization and Genotype Data

Kaisa Litonius, Noora Kulla, Petra Falkenbach, Kati Kristiansson, E. Katriina Tarkiainen, Liisa Ukkola-Vuoti, Kristiina Cajanus, Mari Korhonen, Sofia Khan, Johanna Sistonen, Arto Orpana, Mats Lindstedt, Tommi Nyrönen, Markus Perola, Miia Turpeinen, Ville Kytö, Aleksi Tornio, Mikko Niemi, 
  •  4 October 2024

Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Studies Related to Vincristine-Induced Peripheral Neuropathy in Chinese Pediatric ALL Patients

Yawen Yuan, Wenting Hu, Changcheng Chen, Ruen Yao, Shunguo Zhang, Xiao Zhu, Bulong Xu, Zhonghui Huang, Shengyuan Zhang, Xuexian Wang, Mei Zheng, Xiaohui Huang, Joseph F. Standing, 
  •  4 October 2024
Open access

Pharmacokinetic, Safety, and Pharmacodynamic Profiles of Saroglitazar Magnesium in Cholestatic Cirrhosis With Hepatic Impairment and Participants With Renal Impairment

Raj Vuppalanchi, Mary M. Cruz, Taufik Momin, Farheen Shaikh, Kimberly Swint, Harilal Patel, Deven Parmar, 
  •  2 October 2024

New Drug Development Strategy in Japan: Flexibility in Guideline Adherence

Mihoko Kobayashi, Mamoru Narukawa, 
  •  2 October 2024
Open access

Reply to: “Questioning Conclusions and Statements on the German HTA System: A Critical Perspective”

James Harnett, Julien Heidt, Ruben G. W. Quek, Laura Walsh, 
  •  1 October 2024
No abstract is available for this article.
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk, 
  •  127-134
  •  13 May 2015
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Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang, 
  •  1095-1105
  •  17 November 2018
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Ursula Amstutz, Linda M. Henricks, Steven M. Offer, Julia Barbarino, Jan H.M. Schellens, Jesse J. Swen, Teri E. Klein, Howard L. McLeod, Kelly E. Caudle, Robert B. Diasio, Matthias Schwab, 
  •  210-216
  •  20 November 2017
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