Clinical Pharmacology & Therapeutics (CPT), the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT), is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics.

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

Browse Articles

Industry Perspective on First‐in‐Human and Clinical Pharmacology Strategies to Support Clinical Development of T‐Cell Engaging Bispecific Antibodies for Cancer Therapy

Prathap Nagaraja Shastri, Nirav Shah, Martin Lechmann, Hardik Mody, Marc W. Retter, Min Zhu, Tommy Li, Jun Wang, Naveed Shaik, Xirong Zheng, Meric Ovacik, Fei Hua, Vibha Jawa, Christophe Boetsch, Yanguang Cao, John Burke, Kaushik Datta, Kapil Gadkar, Vijay Upreti, Alison Betts, 
  •  19 September 2024
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Issue Information

  •  875-880
  •  17 September 2024
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ASCPT News

  •  892-896
  •  17 September 2024
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Is Pharmacogenetic Testing a Vital Tool for Enhancing Therapeutic Management of Patients Worldwide?

Kathleen M. Giacomini, Piet H. van der Graaf, 
  •  885-889
  •  17 September 2024
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Highlighted Articles

  •  890-891
  •  17 September 2024
No abstract is available for this article.
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk, 
  •  127-134
  •  13 May 2015
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Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang, 
  •  1095-1105
  •  17 November 2018
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

Ursula Amstutz, Linda M. Henricks, Steven M. Offer, Julia Barbarino, Jan H.M. Schellens, Jesse J. Swen, Teri E. Klein, Howard L. McLeod, Kelly E. Caudle, Robert B. Diasio, Matthias Schwab, 
  •  210-216
  •  20 November 2017
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