Journal Overview

Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).

Featured in Clinical Pharmacology & Therapeutics

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

Browse Articles

Population Pharmacokinetics and Exposure–Response Analysis for the CTLA‐4 Inhibitor Tremelimumab in Metastatic NSCLC Patients in the Phase III POSEIDON Study

Jimmy Zhijian He, Vincent Duval, Petra Jauslin, Antonio Gonçalves, Aburough Abegesah, Chunling Fan, KyoungSoo Lim, Xuyang Song, Cecil Chen, Xiaojin Shi, Helen Mann, Lee Krug, Song Ren, Alex Phipps, Megan Gibbs, Diansong Zhou, 
  •  30 September 2023

Determination and Confirmation of Recommended Ph2 Dose of Amivantamab in Epidermal Growth Factor Receptor Exon 20 Insertion Non‐Small Cell Lung Cancer

Nahor Haddish-Berhane, Yaming Su, Alberto Russu, Meena Thayu, Roland E. Knoblauch, Jaydeep Mehta, John Xie, Eric Gibbs, Yu-Nien Sun, Honghui Zhou, 
  •  30 September 2023

Model‐informed selection of the recommended phase 3 dose of the inhibitor of apoptosis protein inhibitor, xevinapant, in combination with cisplatin and concurrent radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck

Yulia Vugmeyster, Abhigyan Ravula, Elisabeth Rouits, Paul Matthias Diderichsen, Huub Jan Kleijn, Andre Koenig, XiaoZhe Wang, Andreas Schroeder, Kosalaram Goteti, Karthik Venkatakrishnan, 
  •  30 September 2023

Individualized use of 6‐mercaptopurine in Chinese children with ALL: A multicenter randomized controlled trial

Yue Zhou, Li Wang, Li-Rong Sun, Li Zhang, Hong-Mei Wang, Xi-Ting Liu, Fan Yang, Ke-Liang Wu, Yu-Li Liang, Bei-Bei Zhao, Yong Zhuang, Jin-Qiu Fu, Chao Song, Yun Li, Ling-Zhen Wang, Hui-Juan Xu, Yan Gu, John van den Anker, Xiu-Li Ju, Xiao-Fan Zhu, Wei Zhao, 
  •  27 September 2023

CAR T‐cell therapy for multiple myeloma: A clinical practice‐oriented review

Norah Layla Sadek MD, Bruno Almeida Costa MD, Karthik Nath MBBS, PhD, Sham Mailankody MBBS, 
  •  26 September 2023
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk, 
  •  127-134
  •  13 May 2015
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Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang, 
  •  1095-1105
  •  17 November 2018
free access

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

JK Hicks, K Sangkuhl, JJ Swen, VL Ellingrod, DJ Müller, K Shimoda, JR Bishop, ED Kharasch, TC Skaar, A Gaedigk, HM Dunnenberger, TE Klein, KE Caudle, JC Stingl, 
  •  37-44
  •  20 December 2016
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Population Pharmacokinetics and Exposure–Response Analysis for the CTLA‐4 Inhibitor Tremelimumab in Metastatic NSCLC Patients in the Phase III POSEIDON Study

Jimmy Zhijian He, Vincent Duval, Petra Jauslin, Antonio Gonçalves, Aburough Abegesah, Chunling Fan, KyoungSoo Lim, Xuyang Song, Cecil Chen, Xiaojin Shi, Helen Mann, Lee Krug, Song Ren, Alex Phipps, Megan Gibbs, Diansong Zhou, 

Determination and Confirmation of Recommended Ph2 Dose of Amivantamab in Epidermal Growth Factor Receptor Exon 20 Insertion Non‐Small Cell Lung Cancer

Nahor Haddish-Berhane, Yaming Su, Alberto Russu, Meena Thayu, Roland E. Knoblauch, Jaydeep Mehta, John Xie, Eric Gibbs, Yu-Nien Sun, Honghui Zhou, 

Model‐informed selection of the recommended phase 3 dose of the inhibitor of apoptosis protein inhibitor, xevinapant, in combination with cisplatin and concurrent radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck

Yulia Vugmeyster, Abhigyan Ravula, Elisabeth Rouits, Paul Matthias Diderichsen, Huub Jan Kleijn, Andre Koenig, XiaoZhe Wang, Andreas Schroeder, Kosalaram Goteti, Karthik Venkatakrishnan, 
More articles

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