Journal Overview

Clinical Pharmacology & Therapeutics (CPT) is the flagship journal of the American Society for Clinical Pharmacology and Therapeutics (ASCPT).

Featured in Clinical Pharmacology & Therapeutics

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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study

Biological mechanisms proposed by Carpinteiro et al. underlying the potential inhibition by Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) of cell infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2).

Cost-Sharing Increase, Medication Adherence, and Hospitalizations in Schizophrenia Patients: A Natural Experiment

Patient selection flowchart. SCZ, schizophrenia.

When Can Nonrandomized Studies Support Valid Inference Regarding Effectiveness or Safety of New Medical Treatments?

Valid inference on medication effects from nonrandomized studies. RCT, randomized controlled trial.

Browse Articles

Nafamostat reduces the incidence of post-ERCP pancreatitis: a systematic review and meta-analysis of randomized controlled trials

István László Horváth, Dénes Kleiner, Rita Nagy, Péter Fehérvári, Balázs Hankó, Péter Hegyi, Dezső Csupor, 
  •  30 November 2023

Measurement and Mitigation of Bias in AI: A Narrative Literature Review for Regulatory Science

Magnus Gray, Ravi Samala, Qi Liu, Denny Skiles, Joshua Xu, Weida Tong, Leihong Wu, 
  •  29 November 2023

Higher BST2 Expression Promotes the Anti-HBV Effect of IFN-α and BST2 Genetic Variant Predicts PegIFNα Treatment Response of HBeAg-positive Chronic Hepatitis B Patients

Jiaxuan Chen, Jia Hou, Rong Na, Bin Zhou, Jinlin Hou, De-Ke Jiang, 
  •  29 November 2023

Non‐labelled, Stable Labelled or Radiolabelled Approaches for Provision of Intravenous Pharmacokinetics in Humans: a Discussion Piece

Graeme C. Young, Douglas K. Spracklin, Alexander D. James, Mette G. Hvenegaard, Mette L. Pedersen, David S. Wagner, Katrin Georgi, Hanno Schieferstein, Inga Bjornsdottir, Andrea A. Romeo, Kenneth C. Cassidy, Georges Da-violante, Stefan Blech, Simone I. Schulz, Filip Cuyckens, Mai Anh Nguyen, Graeme Scarfe, 
  •  29 November 2023

Rationale, development, and validation of HdxSim, a clinical decision support tool for model‐informed precision dosing (MIPD) of hydroxyurea for children with sickle cell anemia

Alexandra Power-Hays, Min Dong, Nieko Punt, Tomoyuki Mizuno, Luke R. Smart, Alexander A. Vinks, Russell E. Ware, 
  •  28 November 2023
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors

JK Hicks, JR Bishop, K Sangkuhl, DJ Müller, Y Ji, SG Leckband, JS Leeder, RL Graham, DL Chiulli, A LLerena, TC Skaar, SA Scott, JC Stingl, TE Klein, KE Caudle, A Gaedigk, 
  •  127-134
  •  13 May 2015
free access

Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update

Mary V. Relling, Matthias Schwab, Michelle Whirl-Carrillo, Guilherme Suarez-Kurtz, Ching-Hon Pui, Charles M. Stein, Ann M. Moyer, William E. Evans, Teri E. Klein, Federico Guillermo Antillon-Klussmann, Kelly E. Caudle, Motohiro Kato, Allen E.J. Yeoh, Kjeld Schmiegelow, Jun J. Yang, 
  •  1095-1105
  •  17 November 2018
free access

Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update

JK Hicks, K Sangkuhl, JJ Swen, VL Ellingrod, DJ Müller, K Shimoda, JR Bishop, ED Kharasch, TC Skaar, A Gaedigk, HM Dunnenberger, TE Klein, KE Caudle, JC Stingl, 
  •  37-44
  •  20 December 2016
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More articles

Nafamostat reduces the incidence of post-ERCP pancreatitis: a systematic review and meta-analysis of randomized controlled trials

István László Horváth, Dénes Kleiner, Rita Nagy, Péter Fehérvári, Balázs Hankó, Péter Hegyi, Dezső Csupor, 

Measurement and Mitigation of Bias in AI: A Narrative Literature Review for Regulatory Science

Magnus Gray, Ravi Samala, Qi Liu, Denny Skiles, Joshua Xu, Weida Tong, Leihong Wu, 

Higher BST2 Expression Promotes the Anti-HBV Effect of IFN-α and BST2 Genetic Variant Predicts PegIFNα Treatment Response of HBeAg-positive Chronic Hepatitis B Patients

Jiaxuan Chen, Jia Hou, Rong Na, Bin Zhou, Jinlin Hou, De-Ke Jiang, 
More articles

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