Volume 99, Issue 1 p. 72-81
State of the Art

Protease receptor antagonism to target blood platelet therapies

M Holinstat

M Holinstat

University of Michigan Medical School, Departments of Pharmacology and Internal Medicine, Ann Arbor, Michigan, USA

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PF Bray

Corresponding Author

PF Bray

Thomas Jefferson University, The Cardeza Foundation for Hematologic Research and the Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, USA

Correspondence: PF Bray ([email protected])Search for more papers by this author
First published: 26 October 2015
Citations: 8

Abstract

Platelet activation and thrombus formation play a central role in ischemic vascular disease. Thrombin, an especially potent physiologic agonist mediating in vivo activation of platelets, acts via a unique family of G-protein-coupled receptors called protease-activated receptors (PARs) with a broad tissue expression. This review focuses on current antiplatelet therapies as well as innovative approaches to targeting PARs in patients with atherothrombotic vascular disease.