Virtual Issues

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Tutorials

Last updated:
26 June 2017

Tutorials are educational articles providing practical tutorials on tools, methodologies and approaches in translational medicine. 

Precision Medicine

Last updated:
19 May 2017
The theme of the ASCPT 2017 Annual Meeting is "Advancing Patient Care Through Precision and Translational Medicine". In the spirit of avowing the shared vision of ASCPT's Journal Family around these vital issues relevant to the future of the field, each journal has devoted a portion of its March issue to the subject of Precision Medicine. These articles have been compiled to form the following shared "Virtual Issue," which provides an overview of relevant issues and challenges facing this area of research, as well as opportunities available for pushing forward in order to more effectively identify and treat disease using tools and methodology at the cutting edge of pharmacology, systems biology, and translational medicine.



The Precision Medicine theme is shared between the ASCPT Journal Family. Access the Precision Medicine content from: 

Biomarkers

Last updated:
19 May 2017
Biomarkers have an enormously important role in the definition of translational medicine and serve as the common language of translational sciences. The BEST (Biomarkers, EndpointS, and other Tools) Resource, authored by the FDA-NIH Biomarker Working Group, defines a biomarker as "a defined characteristic that is measured as an indicator of normal biological processes, pathogenic processes, or responses to an exposure or intervention, including therapeutic interventions." Biomarkers serve as the “glue” that adheres many of the component translational disciplines together, and are undergoing a renaissance of increased interest. The uptick in interest in the field of biomarkers is evident in this evolving, state-of-the-art compilation of CTS articles.

Early Clinical Trials

Last updated:
19 May 2017
One of the most dynamic and impactful aspects of translational medicine is early clinical research studies. These clinical studies often establish early proof of concept, including critical components of proof of biology, such as human genetic data and proof of safety. Early clinical trials can also offer reasonable margins to clinical dose, proof of mechanism (particularly target enlargement), and proof of activity, comprised of clinically relevant endpoints or disease-related PD/response biomarkers. The intent of this compilation of CTS articles is to showcase current, evolving, and impactful early clinical studies.

Oncology

Last updated:
19 May 2017
Clinical and translational science is foundational to oncology. Diverse oncology topics, including immune-oncology, precision medicine, early clinical results, and the development of innovative biomarkers, depend on the tenets and practice of translational medicine. The aim of this virtual issue of CTS is to publish cutting edge translational medicine in oncology drug discovery, development, and clinical usage.