PSPod

CPT:PSP is pleased to offer our own podcast, PSPod. Join us as we delve into advances in quantitative methods as applied in pharmacology, physiology and therapeutics in humans.
DISCLAIMER: The Publisher, Society and Editors cannot be held responsible for errors or any consequences arising from the use of information contained in this podcast; the views and opinions expressed do not necessarily reflect those of the Publisher, Society and Editors.

Quantitative Systems Pharmacology and Hematology
Published 11/4/16


This episode features Dr. Satyaprakash Nayak discussing application of advanced pharmacometrics and quantitative systems pharmacology in hematology. Read his article from the July 2016 issue here. Also, please find additional CPT:PSP articles related to hematology in the Hematology Virtual Issue, which is available here.


Good Practices in Model-Informed Drug Discovery and Development
Published 5/9/16


In this episode, Drs. Scott Marshall from Pfizer, Sandra Visser from Merck, and Amy Cheung from AstraZeneca discuss "Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation": Their White Paper published in the March issue of PSP. You can get free access the White Paper by clicking here.


Communicating Systems Pharmacology and Pharmacometrics Models
Published 2/26/16


In this episode, Peter Bonate from Astellas, discusses effective communication in systems pharmacology and pharmacometric models. You can read a review of Dr. Bonate's book Be a Model Communicator and Sell Your Models to Anyone, reviewed by Ellen Leinfuss in the May 2015 issue, by clicking here.


Existing Practice and Modeling Approaches and Future Directions for Modeling to Assess and Predict Cardiovascular Liabilities of New Drugs
Published 1/15/16


This episode features Sandra Visser and Anne Chain from Merck & Co/MSD, discussing existing practice and modeling approaches and some thoughts with regard to future directions for modeling to assess and predict cardiovascular liabilities of new drugs. You can read Dr. Visser's Review "Implementation of Quantitative and Systems Pharmacology in Large Pharma" by clicking here.


The Drug Disease Model Resources (DDMoRe): A Consortium to Create Standards and Tools to Enhance Model-Based Drug Development
Published 9/18/15


This episode features Lutz Harnisch from Clinical Pharmacology Pharmacometrics at Pfizer, discussing the Drug Disease Model Resources (DDMoRe) consortium. His Perspective article that introduces the activities of the DDMoRe consortium can also be found here.


Databases as tools in pharmacometrics and systems pharmacology
Published 6/1/15


In this episode, we interview Dr. Shiew-Mei Huang, Deputy Director, Office of Clinical Pharmacology, Center for Drug Evaluation and Research at the Food and Drug Administration about a drug interaction database--a tool for evaluating the impact of renal or hepatic impairment in a pharmacologic inhibition on the systemic exposure of drugs. Read the article here. An Editorial describing the new Database article type can also be found here.


Infectious diseases and the role of pharmacometrics
Published 3/2/15


In this episode, we interview Dr. Steven E. Kern, Deputy Director of Quantitative Sciences at the Bill and Melinda Gates Foundation, about infectious diseases in context of the possibilities for pharmacometrics and systems pharmacology to contribute to improve treatments in the area.


Predictive systems pharmacology in pediatrics
Published 11/20/14


In this episode, Geoff Marsh interviews Dr. Catherijne Knibbe, from St. Antonius Hospital, about modeling and simulation in pediatric clinical oncology.


Systems Pharmacology Approaches in Oncology
Published 8/21/14


In this episode, Geoff Marsh interviews Dr. James M. Gallo, from The Mount Sinai Hospital, about the application of systems pharmacology approaches to oncology.


Role of PBPK Modeling in Systems Pharmacology
Published 5/22/14


In this podcast, Geoff Marsh interviews Dr. Amin Rostami, of the University of Manchester, about the recent resurgence of physiologically based pharmacokinetic (PBPK) modeling in systems pharmacology.


Mathematical modeling and diabetes
Published 2/20/14


In this podcast, Geoff Marsh interviews Dr. Vijayalakshmi Chelliah, the lead curator of Biomodels Database, at the EMBL- European Bioinformatics Institute about the impact of mathematical modeling on the understanding of diabetes and related complications.


CPT:PSPTutorials
Published 11/19/13


In this podcast, Geoff Marsh interviews Dr. Diane Mould of Projections Research about Tutorials, a new series of articles published in CPT: Pharmacometrics & Systems Pharmacology. Tutorials serve as important educational material on the tools, methodologies, and approaches used for modeling and simulation.