Tutorials

Tutorials are educational articles providing practical tutorial on tools, methodologies, and approaches in pharmacometrics and systems pharmacology. Tutorials aim to increase the awareness and potential of pharmacometrics and systems pharmacology outside the disciplines, introduce methodology to newcomers interested in model-based approaches, and provide further training and specialized guides to those already working in the field.

Listen to the PSPod podcast about CPT:PSP Tutorials.

MAY 2016

A Six-Stage Workflow for Robust Application of Systems Pharmacology
Saroja Ramanujan, Kapil Gadkar, Donald Mager, Piet van der Graaf
CPT: Pharmacometrics Syst. Pharmacol; doi: 10.1002/psp4.12071
Abstract | Full Text | PDF | Supporting Information

APRIL 2016

Communicating to Influence Drug Development and Regulatory Decisions: A Tutorial
Jogarao Gobburu, Shailly Mehrotra
CPT: Pharmacometrics Syst. Pharmacol; doi: 10.1002/psp4.12073
Abstract | Full Text | PDF | Supporting Information

MARCH 2016

Good Practices in Model-Informed Drug Discovery and Development (MID3): Practice, Application and Documentation
Scott Marshall, Rolf Burghaus, Valerie Cosson, Amy Cheung, Marylore Chenel, Oscar Della Pasqua, Nicolas Frey, Bengt Hamre, Lutz Harnisch, Frederic Ivanow, Thomas Kerbusch, Jorg Lippert, Peter Milligan, Solange ROHOU, Alexander Staab, Jean-Louis Steimer, Christoffer Tornoe, Sandra Visser
CPT: Pharmacometrics Syst. Pharmacol; doi: 10.1002/psp4.12049
Abstract | Full Text | PDF | Supporting Information

JANUARY 2016

A Model Qualification Method for Mechanistic Physiological QSP Models to Support Model-Informed Drug Development

Christina Friedrich
CPT Pharmacometrics Syst. Pharmacol. Early View; doi: 10.1002/psp4.12056
Abstract | Full Text | PDF | Supporting Information

DECEMBER 2015

A tutorial on RxODE: Simulating differential equation pharmacometrics models in R
Karen Hallow, Wenping Wang, David James
CPT Pharmacometrics Syst. Pharmacol. doi: 10.1002/psp4.12052
Abstract | Full Text | PDF | Supporting Information

NOVEMBER 2015

The many flavours of model based meta-analysis: Part I - Introduction and Landmark data
Martin Boucher, Meg Bennetts
CPT Pharmacometrics Syst. Pharmacol. Early View; doi: 10.1002/psp4.12041
Abstract | PDF | Supporting Information

Agent based modeling in systems pharmacology
Mr. Jason Cosgrove , Mr. James Butler , Dr. Kieran Alden , Dr. Mark Read , Prof. Vipin Kumar , Dr. Lourdes Cucurull-Sanchez , Prof. Jon Timmis , Dr. Mark Coles
CPT Pharmacometrics Syst. Pharmacol. Early View; doi: 10.1002/psp4.12018
Abstract | Full Text | PDF | Supporting Information

Use of Modeling and Simulation in the Design and Conduct of Pediatric Clinical Trials and the Optimization of Individualized Dosing Regimens
Catherine Sherwin, Chris Stockmann, Jeffrey Barrett, Jessica Roberts, Catherine Sherwin
CPT Pharmacometrics Syst. Pharmacol.; doi: 10.1002/psp4.12038
Abstract | Full Text | PDF | Supporting Information

OCTOBER 2015

Establishing Good Practices for Exposure-Response Analysis of Clinical Endpoints in Drug Development
Steen Ingwersen, Rune Overgaard, Christoffer Tornoe
CPT Pharmacometrics Syst. Pharmacol.; doi: 10.1002/psp4.12015
Abstract | Full Text | PDF | Supporting Information

AUGUST 2015

MatVPC: A User-friendly Matlab-based Tool for the Simulation and Evaluation of Systems Pharmacology Models

Mirjam Trame, Konstantinos Biliouris, Marc Lavielle, Mirjam Trame
CPT Pharmacometrics Syst. Pharmacol. Early View; doi: 10.1002/psp4.12011
Abstract | Full Text | PDF | Supporting Information

Cloud Computing for Pharmacometrics: Using AWS, NONMEM, PsN, Grid Engine and Sonic
Sachin Sanduja, Paul Jewell, Etty Aron, Nicola Pharai
CPT Pharmacometrics Syst. Pharmacol. Early View; doi: 10.1002/psp4.12016
Abstract | Full Text | PDF | Supporting Information

JUNE 2015

A Tutorial on Target-Mediated Drug Disposition (TMDD) Models
Pinky Dua, Emma Hawkins, Piet van der Graaf
CPT Pharmacometrics Syst. Pharmacol. 4: 6; doi: 10.1002/psp4.41
Abstract | Full Text | PDF | Supporting Information

APRIL 2015

Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction
M Sundqvist, A Lundahl, MB Någård, U Bredberg and P Gennemark
CPT Pharmacometrics Syst. Pharmacol. 4: 4; doi:10.1002/psp4.32
Abstract | Full Text | PDF | Supporting Information

MARCH 2015

Interactive Pharmacometric Applications Using R and the Shiny Package
J Wojciechowski, AM Hopkins and RN Upton
CPT Pharmacometrics Syst. Pharmacol. 4: 3; doi:10.1002/psp4.21
Abstract | Full Text | PDF | Supporting Information

FEBRUARY 2015

BioModels: Content, Features, Functionality, and Use
N Juty, R Ali, M Glont, S Keating, N Rodriguez, MJ Swat, SM Wimalaratne, H Hermjakob, N Le Novère, C Laibe and V Chelliah
CPT Pharmacometrics Syst. Pharmacol. 4: 2; 55-68 doi:10.1002/psp4.3
Abstract | Full Text | PDF | Supporting Information

Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models
X-Y Zhang, MN Trame, LJ Lesko and S Schmidt
CPT Pharmacometrics Syst. Pharmacol. 4: 2; 69-79 doi:10.1002/psp4.6
Abstract | Full Text | PDF | Supporting Information

JANUARY 2015

Developing Exposure/Response Models for Anticancer Drug Treatment: Special Considerations
DR Mould, A-C Walz, T Lave, JP Gibbs and B Frame
CPT Pharmacometrics Syst. Pharmacol. 4: 1; 12-27 doi:10.1002/psp4.16
Abstract | Full Text | PDF | Supporting Information

NOVEMBER 2014

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
A R Maharaj and A N Edginton
CPT Pharmacometrics Syst. Pharmacol. 3: e148; doi:10.1038/psp.2014.55
Abstract | Full Text | PDF | Supporting Information

AUGUST 2014

Modeling and Simulation of Count Data
E L Plan
CPT Pharmacometrics Syst. Pharmacol. 3: e129; doi:10.1038/psp.2014.27
Abstract | Full Text | PDF | Supporting Information

JUNE 2014

Exposure–Response Modeling of Clinical End Points Using Latent Variable Indirect Response Models
C Hu
CPT Pharmacometrics Syst. Pharmacol. 3: e117; doi:10.1038/psp.2014.15
Abstract | Full Text | PDF | Supporting Information

MAY 2014

Visualization and Communication of Pharmacometric Models With Berkeley Madonna
A Krause and P J Lowe
CPT Pharmacometrics Syst. Pharmacol. 3: e116; doi:10.1038/psp.2014.13
Abstract | Full Text | PDF | Supporting Information

JANUARY 2014

Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development: Part 3—Introduction to Pharmacodynamic Modeling Methods
R N Upton and D R Mould
CPT: Pharmacomet. Syst. Pharmacol. 3: e88; doi:10.1038/psp.2013.71
Abstract | Full Text | PDF | Supporting Information

DECEMBER 2013

Editorial: Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions
P Vicini, L E Friberg, P H van der Graaf and A Rostami-Hodjegan
CPT: Pharmacomet. Syst. Pharmacol. 2: e86; doi:10.1038/psp.2013.60
Abstract | Full Text | PDF

OCTOBER 2013

Application of ggplot2 to Pharmacometric Graphics
K Ito and D Murphy
CPT: Pharmacomet. Syst. Pharmacol. 2: e79; doi:10.1038/psp.2013.56
Abstract | Full Text | PDF | Supporting Information

AUGUST 2013

Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development
H M Jones and K Rowland-Yeo
CPT: Pharmacomet. Syst. Pharmacol. 2: e63; doi:10.1038/psp.2013.41
Abstract | Full Text | PDF | Supporting Information

JULY 2013

Editorial: Tutorials on the Foundations of Pharmacometrics and Systems Pharmacology
L E Friberg
CPT: Pharmacomet. Syst. Pharmacol. 2: e53; doi:10.1038/psp.2013.27
Abstract | Full Text | PDF

Establishing Best Practices and Guidance in Population Modeling: An Experience With an Internal Population Pharmacokinetic Analysis Guidance
W Byon, M K Smith, P Chan, M A Tortorici, S Riley, H Dai, J Dong, A Ruiz-Garcia, K Sweeney and C Cronenberger
CPT: Pharmacomet. Syst. Pharmacol. 2: e51; doi:10.1038/psp.2013.26
Abstract | Full Text | PDF | Supporting Information

JUNE 2013

Modeling and Simulation Workbench for NONMEM: Tutorial on Pirana, PsN, and Xpose
R J Keizer, M O Karlsson and A Hooker
CPT: Pharmacomet. Syst. Pharmacol. 2: e50; doi:10.1038/psp.2013.24
Abstract | Full Text | PDF | Supporting Information

MAY 2013

A Time to Event Tutorial for Pharmacometricians
N Holford
CPT: Pharmacomet. Syst. Pharmacol. 2: e43; doi:10.1038/psp.2013.18
Abstract | Full Text | PDF | Supporting Information

APRIL 2013

Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development—Part 2: Introduction to Pharmacokinetic Modeling Methods
D R Mould and R N Upton
CPT: Pharmacomet. Syst. Pharmacol. 2: e38; doi:10.1038/psp.2013.14
Abstract | Full Text | PDF | Supporting Information

SEPTEMBER 2012

Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development
D R Mould and R N Upton
CPT: Pharmacomet. Syst. Pharmacol. 1: e6; doi:10.1038/psp.2012.4
Abstract | Full Text | PDF