Clinical Trials

Clinical Trials from CPT


Early Clinical Evaluation of the Intranasal TLR7 Agonist GSK2245035: Use of Translational Biomarkers to Guide Dosing and Confirm Target Engagement

Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase


Differentiating Drug-Induced Multi-channel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine and Verapamil

Pulmonary Penetration of Piperacillin and Tazobactam in Critically Ill Patients

Use of Opportunistic Clinical Data and a Population Pharmacokinetic Model to Support Dosing of Clindamycin for Premature Infants to Adolescents

A Compartmental Pharmacokinetic Evaluation of Long-acting Rilpivirine in HIV Negative Volunteers for Pre-exposure Prophylaxis (PrEP)

Impact of CYP2D6 Polymorphisms on Clinical Efficacy and Tolerability of Metoprolol Tartrate

Erlotinib in African Americans with Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study with Genetic and Pharmacokinetic Analysis

Sorafenib Dose Escalation is Not Uniformly Associated with Blood Pressure Elevations in Normotensive Patients with Advanced Malignancies

Pacemaker Current Inhibition in Experimental Human Cardiac Sympathetic Activation: A Double-blind, Randomized, Crossover Study

Aspirin Decreases the Systemic Exposure to Clopidogrel Through Modulation of P-glycoprotein, but Does not Alter its Antithrombotic Activity


Pharmacogenomics and Translational Simulations to Bridge Indications for an Anti-Interferon Alpha Receptor Antibody

A Randomized Trial on the Acute and Steady-State Effects of a New Antidepressant, Vortioxetine (Lu AA21004), on Actual Driving and Cognition

Contribution of Endogenous Bradykinin to Fibrinolysis, Inflammation and Blood Product Transfusion Following Cardiac Surgery: A Randomized Clinical Trial

First-time-in-Human Study With GSK249320, Myelin Associated Glycoprotein (MAG) Inhibitor in Healthy Volunteers


Proarrhythmic Safety of Repeat Doses of Mirabegron in Healthy Subjects: A Randomized, Double-Blind, Placebo- and Active-Controlled Thorough QT Study

Effect of Adherence Measured by MEMS, Ritonavir Boosting and CYP3A5 Genotype on Atazanavir Pharmacokinetics in Treatment-naïve HIV-infected Patients

The Effect of Safinamide, a Novel Drug for Parkinson's Disease, on Pressor Response to Oral Tyramine: A Randomized, Double-Blind, Clinical Trial

LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients with Type 2 Diabetes in a Randomized, Placebo-controlled Trial

Impact of the β1-Adrenoceptor Arg389Gly Polymorphism on Heart-Rate Responses to Bisoprolol and Carvedilol in Heart-Failure Patients

A Multiple-Ascending-Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of a Novel GPR40 Agonist, TAK-875, in Subjects With Type 2 Diabetes

Orexin Receptor Antagonism, a New Sleep-Enabling Paradigm: A Proof of Concept Clinical Trial

Comparative Impact on Prostanoid Biosynthesis of Celecoxib and the Novel Nonsteroidal Anti-Inflammatory Drug CG100649

Pharmacokinetic and Pharmacodynamic Variability of Fluindione in Octogenarians

Low-Dose Lisinopril in Normotensive Men With Idiopathic Oligospermia and Infertility: A 5-Year Randomized, Controlled, Crossover Pilot Study

High-Dose Ibuprofen for Patent Ductus Arteriosus in Extremely Preterm Infants: A Randomized Controlled Study

The Effects of Extended Pre-Quit Varenicline Treatment on Smoking Behavior and Short-Term Abstinence: A Randomized Clinical Trial


A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L-Menthol in Upper Gastrointestinal Endoscopy

A Randomized Study of the Efficacy and Safety of Intravenous Acetaminophen vs. Intravenous Placebo for the Treatment of Fever

The Innate Immune Response, Clinical Outcomes and ex-vivo HCV Antiviral Efficacy of a TLR7 agonist (PF-4878691)