Although the critical role of the immune system in cancer has long been recognized, the development of novel oncological pharmacotherapies through specifically targeting the immune system is a relatively new area of research. Key challenges for the effective translation of emerging science into efficient drug development include:
- Identification of novel targets and optimal dosing regiments for combination therapies
- Individualized dosing and prediction and management of the therapeutic window in special patient populations
- Identification of subgroups of patients most likely to benefit through use of biomarkers, diagnostic and precision medicine
This immuno-oncology virtual issue of CPT-PSP contains original research articles, case studies, reviews and tutorials of cutting-edge pharmacometric and systems pharmacology approaches spanning the R&D continuum from drug discovery to development as well as regulatory approval and clinical use.