Safety Pharmacology

Last Updated:
4 May 2017
In addition to its growing use and impact in predicting and optimizing drug efficacy, pharmacometrics and systems pharmacology is also increasingly being applied to define and maximize the benefit-risk profile of pharmacological interventions through quantitative assessment of safety liabilities. Model-based approaches such as exposure-response analysis, physiologically-based pharmacokinetics (PBPK), quantitative systems toxicology (QST) and bio-informatics are now being applied across the R&D spectrum and should contribute to the development of safer medicines. The rapid expansion of the drugable target space into novel areas of biology and pathophysiology requires a parallel development of innovative predictive quantitative frameworks for safety and toxicology. The aim of this virtual issue of CPT:PSP is to publish cutting edge development and application of such methods in drug discovery and development and clinical usage, as well as providing readers with state-of-the-art overviews and tutorials.
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