Hematology is the branch of medicine concerned with disorders of blood and bone marrow, for example anemia, coagulation disorders, and cancers such as leukemia. Pharmacometrics and quantitative systems pharmacology (QSP) are increasingly being used in model-informed drug discovery and development (MID3) of novel hematological drugs, but also as clinical tools to optimise the use of existing therapies. The links between quantitative pharmacology and hematology were established more than a century ago when A.V. Hill published a mathematical model for the sigmoidal binding of oxygen to haemoglobin, which (known as the “Hill equation”) became one of the central equations in pharmacometrics and QSP.
This virtual issue of CPT:PSP provides an up-to-date overview of the breadth and depth of state-of-the-art application of advanced pharmacometrics and QSP in hematology in drug discovery, development, and clinical practise.