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Clinical Pharmacology & Therapeutics (CPT) is the authoritative cross-disciplinary journal in experimental and clinical medicine devoted to publishing advances in the nature, action, efficacy, and evaluation of therapeutics.

CPT: Pharmacometrics & Systems Pharmacology (CPT:PSP) is a timely online-only, cross-disciplinary journal devoted to publishing advances in quantitative methods as applied in pharmacology, physiology, and therapeutics in humans.

Clinical and Translational Science (CTS) highlights original research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease.

ASCPT logo Precision Medicine Joint Issue

The theme of the ASCPT 2017 Annual Meeting is “Advancing Patient Care Through Precision and Translational Medicine”. In the spirit of avowing the shared vision of ASCPT’s Journal Family around these vital issues relevant to the future of the field, each journal has devoted a portion of its March issue to the subject of Precision Medicine. These articles have been compiled to form the following shared “Virtual Issue,” which provides an overview of relevant issues and challenges facing this area of research, as well as opportunities available for pushing forward in order to more effectively identify and treat disease using tools and methodology at the cutting edge of pharmacology, systems biology, and translational medicine.


Clinical Pharmacology & Therapeutics

Precision Medicine—Nobody Is Average
AA Vinks

Use of Precision Medicine Molecular Profiling of Baseline Tumor Specimen May Not Benefit Outcomes in Children With Relapsed or Refractory Pediatric Sarcomas
J Carter, L Cheng, J Zucker, M Marshall, K Pollok, M Murray, L Li, J Renbarger

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium
CH van der Wouden, A Cambon-Thomsen, E Cecchin, KC Cheung, CL Dávila-Fajardo, VH Deneer, V Dolžan, M Ingelman-Sundberg, S Jönsson, MO Karlsson, M Kriek, C Mitropoulou, GP Patrinos, M Pirmohamed, M Samwald, E Schaeffeler, M Schwab, D Steinberger, J Stingl, G Sunder-Plassmann, G Toffoli, RM Turner, MH van Rhenen, JJ Swen, H-J Guchelaar, on behalf of the Ubiquitous Pharmacogenomics Consortium

Learning Health Systems as Facilitators of Precision Medicine
LB Ramsey, T Mizuno, AA Vinks, PA Margolis

Scalpels Not Hammers: The Way Forward for Precision Drug Prescription
M Neely


CPT: Pharmacometrics & Systems Pharmacology

Precision Medicine in Pharmacometrics and Systems Pharmacology
L Li

Implementing Genomic Clinical Decision Support for Drug-Based Precision Medicine
RR Freimuth, CM Formea, JM Hoffman, E Matey, JF Peterson, RD Boyce

IODNE: An Integrated Optimization Method for Identifying the Deregulated Subnetwork for Precision Medicine in Cancer
S Mounika Inavolu, J Renbarger, M Radovich, V Vasudevaraja, GH Kinnebrew, S Zhang, L Cheng

Systems Pharmacology‐Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes
J Fang, C Cai, Q Wang, P Lin, Z Zhao, F Cheng

CATTLE (CAncer Treatment Treasury with Linked Evidence): An Integrated Knowledge Base for Personalized Oncology Research and Practice
E Soysal, H‐J Lee, Y Zhang, L‐C Huang, X Chen, Q Wei, W Zheng, JT Chang, T Cohen, J Sun, H Xu



Clinical and Translational Science

Translating Precision
MA Pacanowski

Personalised Medicine in Europe
E Nimmesgern, I Benediktsson, I Norstedt

In Pursuit of Greater Reproducibility and Credibility of Early Clinical Biomarker Research
LM McShane

The Missing -Omes: Proposing Social and Environmental Nomenclature in Precision Medicine
MM Davis, TP Shanley

Leveraging Genomic Factors to Improve Benefit–Risk
RN Schuck, R Charlab, GM Blumenthal

High‐Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic‐Driven Medicine
J Ipe, M Swart, KS Burgess, TC Skaar

Current Status of Companion and Complementary Diagnostics: Strategic Considerations for Development and Launch
H Scheerens, A Malong, K Bassett, Z Boyd, V Gupta, J Harris, C Mesick, S Simnett, H Stevens, H Gilbert, P Risser, R Kalamegham, J Jordan, J Engel, S Chen, L Essioux, JA Williams

A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans
S Ryu, S Park, JH Lee, YR Kim, HS Na, HS Lim, HY Choi, IY Hwang, JG Lee, ZW Park, WY Oh, JM Kim, SE Choi

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2017 ASCPT Annual Meeting